EXO5

Across TCGA patient cohorts, EXO5 mutation is significantly associated with the RNA expression of many other genes, with 935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXO5-associated genes across cancer lineages are CYCSP49, CD3G, and AQP7P4. Each is linked with EXO5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXO5-to-partner and partner-to-EXO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP49 grouped by EXO5-low versus EXO5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXO5→partner) and Y-score (partner→EXO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CYCSP49 →	+0.193	+5.557	<.001	.001	3	2
UCEC	CD3G →	+0.712	+4.000	<.001	<.001	3	2
SKCM	AQP7P4 →	+0.073	+3.837	<.001	<.001	3	2
UCEC	PTPRC →	+0.766	+3.338	.009	.005	3	2
UCEC	TRBV7-9 →	+0.992	+3.593	<.001	.001	3	2
LUSC	RNA5SP35 →	+0.525	+5.273	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 935 associations by consensus.

CYCSP49 by EXO5 expression — COAD

Explore this box plot interactively →