EVPL

Across TCGA cell cohorts, EVPL mutation is significantly associated with the RNA expression of many other genes, with 3,151 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EVPL-associated genes across cancer lineages are ACYP1, SERPINA12, and H2AZ1. Each is linked with EVPL in more than 2 cancer types. Because this analysis shows association rather than direction, both EVPL-to-partner and partner-to-EVPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACYP1 grouped by EVPL-low versus EVPL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVPL→partner) and Y-score (partner→EVPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACYP1 →	+0.594	+3.228	.002	.004	3	3
BLOOD_Leukemia	SERPINA12 →	+0.015	+2.338	.004	.002	3	3
LARGE_INTESTINE	H2AZ1 →	+0.435	+1.721	.009	.003	3	3
LARGE_INTESTINE	MAD2L1 →	+0.567	+1.721	.001	.003	3	3
LARGE_INTESTINE	CNOT10 →	+0.503	+2.130	<.001	<.001	3	3
URINARY_TRACT	MPC1L →	+0.062	+4.087	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,151 associations by consensus.

ACYP1 by EVPL expression — BLOOD_Leukemia

Explore this box plot interactively →