EVPL

Across TCGA pan-cancer cohorts, EVPL RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated EVPL data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher EVPL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EVPL expression acts as an unfavorable survival marker, although some lineages such as LUSC and THCA show a favorable association.

SKCM, ACC, and PAAD are the cancer types where EVPL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.273	0.392	<.001	44	view →
ACC	DFS	Median	IV	0.108	0.453	.019	28	view →
PAAD	DFS	Quartile	All	0.199	0.477	.003	25	view →
KIRC	DFS	Quartile	II,III,IV	0.706	0.837	.014	22	view →
LUSC	DFS	Tertile	II,III,IV	0.801	0.661	.020	16	view →
MESO	DFS	Median	III,IV	0.245	0.596	.017	12	view →
THCA	DFS	Tertile	All	0.900	0.699	.030	11	view →
SARC	DFS	Quartile	All	0.704	0.543	.014	11	view →
UCEC	OS	Median	IV	0.620	0.276	.021	10	view →
COAD	DFS	Quartile	II,III,IV	0.598	0.804	.013	9	view →
LGG	DFS	Median	All	0.662	0.784	.009	8	view →
READ	OS	Tertile	All	1.000	0.789	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

EVPL–SKCM (OS)

Open the SKCM breakdown →