EVI5L

Across TCGA patient cohorts, EVI5L mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EVI5L-associated genes across cancer lineages are 4E-BP1, eIF4E, and NF2. Each is linked with EVI5L in more than 2 cancer types. Because this analysis shows association rather than direction, both EVI5L-to-partner and partner-to-EVI5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by EVI5L-low versus EVI5L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVI5L→partner) and Y-score (partner→EVI5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.355	+3.906	<.001	<.001	3	3
UCEC	eIF4E →	+0.181	+1.716	.008	.003	3	2
UCEC	NF2 →	+0.220	+1.906	.001	.014	3	2
UCEC	p70-S6K →	+0.168	+1.742	.007	.002	3	2
UCEC	P-Cadherin →	-0.172	-3.906	<.001	<.001	3	2
UCEC	Rad50 →	-0.182	-1.459	.020	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1 by EVI5L expression — UCEC

Explore this box plot interactively →