EVI5

Across TCGA cell cohorts, EVI5 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EVI5-associated genes across cancer lineages are VSIG4, BEND2, and FAM149A. Each is linked with EVI5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EVI5-to-partner and partner-to-EVI5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSIG4 grouped by EVI5-low versus EVI5-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVI5→partner) and Y-score (partner→EVI5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VSIG4 →	+0.352	+4.421	<.001	.004	3	1
BREAST	BEND2 →	+0.046	+4.421	<.001	.004	3	1
LARGE_INTESTINE	FAM149A →	+1.478	+3.082	<.001	.007	3	1
LARGE_INTESTINE	ACOT2 →	-1.406	-3.169	<.001	.009	3	1
LARGE_INTESTINE	ALKBH7 →	+0.595	+3.364	<.001	.002	3	1
LARGE_INTESTINE	GALR3 →	+0.102	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

VSIG4 by EVI5 expression — BREAST

Explore this box plot interactively →