EVI2A

Across TCGA patient cohorts, EVI2A mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible EVI2A-associated genes across cancer lineages are MTCYBP14, MIR599, and MIR4662B. Each is linked with EVI2A in more than 1 cancer types. Because this analysis shows association rather than direction, both EVI2A-to-partner and partner-to-EVI2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP14 grouped by EVI2A-low versus EVI2A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVI2A→partner) and Y-score (partner→EVI2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MTCYBP14 →	+0.043	+4.859	<.001	.004	3	2
CESC	MIR599 →	+0.458	+6.144	<.001	.001	3	2
UCEC	MIR4662B →	+0.440	+4.877	<.001	.003	3	2
BLCA	OR11H12 →	+0.031	+4.314	<.001	.009	3	2
BLCA	EEF1E1-BLOC1S5 →	+0.054	+4.691	<.001	.001	3	2
BLCA	MIR1267 →	+0.357	+5.455	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

MTCYBP14 by EVI2A expression — BLCA

Explore this box plot interactively →