EVI2A

Across TCGA pan-cancer cohorts, EVI2A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of EVI2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EVI2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EVI2A is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where EVI2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EVI2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.320	<.001	12	view →
COAD	Female	All	−1.293	<.001	9	view →
LUSC	Male	III,IV	−2.410	<.001	8	view →
KIRP	Male	All	+1.209	<.001	7	view →
LUAD	Female	III,IV	−1.184	<.001	6	view →
BRCA	Female	All	+0.729	<.001	6	view →
PAAD	All	All	−1.710	.037	4	view →
THCA	Male	IV	+1.876	.001	3	view →
STAD	Female	All	+1.238	.022	3	view →
READ	Female	All	−1.690	.018	2	view →
UCEC	All	All	−0.806	<.001	2	view →
HNSC	Female	II,III,IV	+0.766	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

EVI2A–KIRC

Open the KIRC breakdown →