EVC

Across TCGA cell cohorts, EVC mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EVC-associated genes across cancer lineages are H4C6, OR2S2, and CD300LD. Each is linked with EVC in more than 1 cancer types. Because this analysis shows association rather than direction, both EVC-to-partner and partner-to-EVC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C6 grouped by EVC-low versus EVC-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EVC→partner) and Y-score (partner→EVC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	H4C6 →	+0.324	+3.793	<.001	.007	3	2
PANCREAS	OR2S2 →	+0.020	+5.614	<.001	.002	3	1
OESOPHAGUS	CD300LD →	+0.013	+4.906	<.001	.006	3	1
LARGE_INTESTINE	GCAT →	+1.133	+2.628	.002	.002	3	1
LARGE_INTESTINE	HSCB →	+0.546	+3.321	.002	.003	3	1
LARGE_INTESTINE	RPL3 →	+0.426	+3.237	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

H4C6 by EVC expression — SKIN

Explore this box plot interactively →