ETV6

Across TCGA patient cohorts, ETV6 mutation is significantly associated with the RNA expression of many other genes, with 1,661 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV6-associated genes across cancer lineages are TUBGCP5, ACSL3, and ZNF516-DT. Each is linked with ETV6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ETV6-to-partner and partner-to-ETV6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBGCP5 grouped by ETV6-low versus ETV6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV6→partner) and Y-score (partner→ETV6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBGCP5 →	+0.340	+2.233	.003	.005	3	3
UCEC	ACSL3 →	+0.462	+2.753	.003	.002	3	3
COAD	ZNF516-DT →	+0.364	+3.268	<.001	.008	3	2
UCEC	RNA5SP351 →	+0.273	+1.523	<.001	.008	3	2
CESC	MIR4435-1 →	+0.256	+4.144	<.001	.009	3	2
UCEC	COPS8P1 →	+0.056	+1.640	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,661 associations by consensus.

TUBGCP5 by ETV6 expression — UCEC

Explore this box plot interactively →