ETV5

Across TCGA patient cohorts, ETV5 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,667 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ETV5-associated proteins across cancer lineages are SPRY4_S280, CTHRC1, and ETV5_S248. Each is linked with ETV5 in more than 5 cancer types. Because this analysis shows association rather than direction, both ETV5-to-partner and partner-to-ETV5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ETV5 versus SPRY4_S280 in GBM, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV5→partner) and Y-score (partner→ETV5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPRY4_S280 →	+0.909	+0.747	<.001	<.001	3	6
COAD	CTHRC1 →	+1.018	+1.136	<.001	<.001	3	6
HNSC	ETV5_S248 →	+0.698	+0.887	.003	.009	3	6
HNSC	TRIM2 →	+0.596	+0.986	<.001	<.001	3	5
CCRCC	NRP2 →	+0.613	+0.582	<.001	<.001	3	5
CCRCC	SDF2 →	+0.434	+0.539	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,667 associations by consensus.

ETV5 vs SPRY4_S280 — GBM

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