ETV5

Across TCGA pan-cancer cohorts, ETV5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ETV5 data layer compared with 6 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ETV5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ETV5 expression acts as an unfavorable survival marker, although some lineages such as THCA and OV show a favorable association.

BLCA, ACC, and LIHC are the cancer types where ETV5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	III,IV	0.460	0.729	.002	107	view →
ACC	DFS	Median	All	0.325	0.839	<.001	99	view →
LIHC	OS	Median	All	0.701	0.848	<.001	78	view →
KICH	DFS	Median	III,IV	0.308	0.942	.001	55	view →
THCA	OS	Tertile	III,IV	1.000	0.864	.001	52	view →
HNSC	OS	Median	All	0.482	0.714	.001	43	view →
LGG	OS	Median	All	0.734	0.879	<.001	35	view →
PAAD	OS	Quartile	All	0.416	0.718	.004	32	view →
COAD	DFS	Median	All	0.629	0.747	.004	30	view →
STAD	DFS	Quartile	All	0.186	0.771	<.001	17	view →
KIRC	DFS	Tertile	IV	0.330	0.611	.012	15	view →
OV	DFS	Quartile	II,III,IV	0.600	0.485	.015	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ETV5–BLCA (OS)

Open the BLCA breakdown →