ETV5

Across TCGA patient cohorts, ETV5 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV5-associated genes across cancer lineages are PCNA, PDCD4, and Tuberin. Each is linked with ETV5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ETV5-to-partner and partner-to-ETV5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ETV5-low versus ETV5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV5→partner) and Y-score (partner→ETV5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.239	+1.765	.003	.014	3	3
UCEC	PDCD4 →	-0.586	-3.700	<.001	.001	3	2
COAD	Tuberin →	-0.327	-3.161	.038	.019	3	2
COAD	Caspase-7-cleavedD198 →	+1.214	+2.824	.001	.034	3	2
UCEC	GAPDH →	+0.532	+2.700	.008	.005	3	2
UCEC	mTOR_pS2448 →	-0.168	-2.209	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

PCNA by ETV5 expression — UCEC

Explore this box plot interactively →