ETV5

Across TCGA cell cohorts, ETV5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,896 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ETV5-associated GO terms across cancer lineages are Negative regulation of lens fiber cell differentiation, Regulation of lens fiber cell differentiation, and Response to nitrosative stress. Each is linked with ETV5 in more than 14 cancer types. Because this analysis shows association rather than direction, both ETV5-to-partner and partner-to-ETV5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of lens fiber cell differentiation grouped by ETV5-low versus ETV5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV5→partner) and Y-score (partner→ETV5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of lens fiber cell differentiation →	+1.153	+2.269	<.001	<.001	3	15
BLOOD_Myeloma	Regulation of lens fiber cell differentiation →	+1.174	+2.610	.002	<.001	2	14
BREAST	Response to nitrosative stress →	+0.172	+2.025	<.001	<.001	3	12
BREAST	Positive regulation of peptidyl-serine phosphorylation →	+0.101	+1.550	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Host-mediated suppression of viral proces →	+0.181	+1.885	.003	.001	3	9
KIDNEY	RNA surveillance →	+0.065	+1.736	<.001	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,896 associations by consensus.

Negative regulation of lens fiber cell differentiation by ETV5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →