ETV5

Across TCGA cell cohorts, ETV5 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ETV5-associated genes across cancer lineages are BHLHA9, ODAM, and CHIA. Each is linked with ETV5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETV5-to-partner and partner-to-ETV5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHA9 grouped by ETV5-low versus ETV5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV5→partner) and Y-score (partner→ETV5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BHLHA9 →	+0.119	+2.247	<.001	.007	3	2
CNS	ODAM →	+0.913	+2.938	<.001	.003	3	2
URINARY_TRACT	CHIA →	+1.476	+5.087	<.001	.004	3	1
LUNG_SCLC	DCD →	+1.446	+5.643	<.001	.002	3	1
LUNG_SCLC	BPIFB6 →	+0.023	+5.029	<.001	.006	3	1
LUNG_SCLC	FTMT →	+0.177	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

BHLHA9 by ETV5 expression — LARGE_INTESTINE

Explore this box plot interactively →