ETV5-AS1

Across TCGA pan-cancer cohorts, ETV5-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ETV5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ETV5-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ETV5-AS1 is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.

HNSC, BRCA, and LUSC are the cancer types where ETV5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ETV5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.132	<.001	10	view →
BRCA	All	III,IV	−0.518	<.001	6	view →
LUSC	All	All	−0.313	<.001	5	view →
CHOL	All	II,III,IV	+0.875	.002	4	view →
THCA	All	All	+0.287	.001	4	view →
LUAD	Female	II,III,IV	−0.441	.025	3	view →
KIRC	All	All	+0.097	.003	3	view →
STAD	Male	II,III,IV	+0.215	.044	1	view →
BLCA	All	III,IV	+0.123	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ETV5-AS1–HNSC

Open the HNSC breakdown →