ETV4

Across TCGA cell cohorts, ETV4 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ETV4-associated genes across cancer lineages are EPPIN, ACTRT1, and TRIM42. Each is linked with ETV4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETV4-to-partner and partner-to-ETV4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPPIN grouped by ETV4-low versus ETV4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV4→partner) and Y-score (partner→ETV4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	ACTRT1 →	+0.038	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TRIM42 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR1M1 →	+0.036	+5.969	<.001	.001	3	1
BLOOD_Leukemia	LRRC55 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.113	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EPPIN by ETV4 expression — BLOOD_Leukemia

Explore this box plot interactively →