ETV3

Across TCGA patient cohorts, ETV3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETV3-associated genes across cancer lineages are MEK1, VHL, and Caspase-7-cleavedD198. Each is linked with ETV3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETV3-to-partner and partner-to-ETV3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ETV3-low versus ETV3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV3→partner) and Y-score (partner→ETV3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.323	+2.321	.021	.033	3	1
UCEC	VHL →	-1.163	-3.000	<.001	<.001	3	1
UCEC	Caspase-7-cleavedD198 →	+0.638	+1.720	.005	.025	3	1
UCEC	Caspase-8 →	-0.205	-2.780	.033	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MEK1 by ETV3 expression — UCEC

Explore this box plot interactively →