ETV2

Across TCGA cell cohorts, ETV2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,281 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ETV2-associated GO terms across cancer lineages are Positive regulation of endopeptidase activity, Mitochondrial proton-transporting ATP synthase complex assembly, and Proton-transporting ATP synthase complex assembly. Each is linked with ETV2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ETV2-to-partner and partner-to-ETV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of endopeptidase activity grouped by ETV2-low versus ETV2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ETV2→partner) and Y-score (partner→ETV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of endopeptidase activity →	+0.214	+0.669	.001	<.001	3	8
BLOOD_Leukemia	Mitochondrial proton-transporting ATP synthase complex assembly →	+0.061	+0.480	.001	.006	3	7
BLOOD_Leukemia	Proton-transporting ATP synthase complex assembly →	+0.061	+0.480	.001	.006	3	7
CNS	Response to aluminum ion →	+0.095	+0.643	.002	<.001	3	7
CNS	Regulation of oocyte maturation →	+0.188	+0.414	.002	<.001	3	7
BLOOD_Myeloma	Ascorbate homeostasis →	+0.189	+0.478	.005	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,281 associations by consensus.

Positive regulation of endopeptidase activity by ETV2 expression — STOMACH

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