ETV2

Across TCGA pan-cancer cohorts, ETV2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ETV2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ETV2 RNA is repressed in tumor relative to normal tissue. In most cancer types ETV2 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, COAD, and KICH are the cancer types where ETV2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ETV2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	−0.630	<.001	9	view →
COAD	All	II,III,IV	+0.386	.001	9	view →
KICH	Female	II,III,IV	−1.135	<.001	8	view →
LIHC	Male	II,III,IV	+0.914	<.001	8	view →
THCA	Male	III,IV	−0.495	<.001	8	view →
LUSC	All	II,III,IV	+0.503	<.001	7	view →
PAAD	All	All	+0.412	.023	4	view →
BLCA	All	All	+0.419	.028	3	view →
UCEC	All	All	+0.310	.017	2	view →
BRCA	Female	All	+0.142	.009	2	view →
CHOL	All	All	+0.444	.012	1	view →
KIRP	All	All	−0.196	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ETV2–HNSC

Open the HNSC breakdown →