ETS1

Across TCGA pan-cancer cohorts, ETS1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ETS1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ETS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ETS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where ETS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.772	0.262	<.001	74	view →
PDAC	DFS	Tertile	II,III,IV	0.649	0.302	.002	17	view →
LUAD	DFS	Quartile	All	0.790	0.465	.002	16	view →
HNSC	DFS	Tertile	All	0.902	0.991	.023	8	view →
GBM	DFS	Tertile	All	0.225	0.411	.008	5	view →
LSCC	OS	Quartile	II,III,IV	0.537	0.865	.031	4	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.329	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ETS1–CCRCC (DFS)

Open the CCRCC breakdown →