ETS1

Across TCGA pan-cancer cohorts, ETS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ETS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ETS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ETS1 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where ETS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ETS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.345	<.001	12	view →
KIRC	Female	All	+1.335	<.001	11	view →
LUSC	Female	All	−1.973	<.001	8	view →
KICH	Female	All	−1.735	<.001	8	view →
STAD	Male	II,III,IV	+1.584	<.001	8	view →
LUAD	Female	II,III,IV	−1.021	<.001	7	view →
BRCA	All	III,IV	−0.676	<.001	6	view →
KIRP	Male	All	−0.950	<.001	5	view →
UCEC	All	All	−1.451	<.001	4	view →
COAD	Female	All	−0.813	<.001	4	view →
ESCA	All	All	+1.447	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ETS1–HNSC

Open the HNSC breakdown →