ETS1

Across TCGA patient cohorts, ETS1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ETS1-associated genes across cancer lineages are BRD4, FOXO3a_pS318_S321, and Notch1. Each is linked with ETS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ETS1-to-partner and partner-to-ETS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRD4 grouped by ETS1-low versus ETS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETS1→partner) and Y-score (partner→ETS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRD4 →	+0.213	+1.807	.006	.023	3	3
UCEC	FOXO3a_pS318_S321 →	-0.105	-1.575	.003	.002	3	2
UCEC	Notch1 →	+0.130	+2.147	.001	<.001	3	2
UCEC	ASNS →	+0.335	+1.392	.001	.017	3	2
UCEC	C-Raf →	+0.146	+1.938	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.069	-1.475	.015	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

BRD4 by ETS1 expression — UCEC

Explore this box plot interactively →