ETS1

Across TCGA cell cohorts, ETS1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ETS1-associated genes across cancer lineages are CLC, KLHL1, and FAM47A. Each is linked with ETS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ETS1-to-partner and partner-to-ETS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLC grouped by ETS1-low versus ETS1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ETS1→partner) and Y-score (partner→ETS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CLC →	+0.582	+3.523	.001	.009	3	1
OESOPHAGUS	KLHL1 →	+0.018	+3.836	<.001	.004	3	1
OESOPHAGUS	FAM47A →	+0.009	+3.392	<.001	.007	3	1
OESOPHAGUS	DYTN →	+0.086	+3.857	<.001	.002	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.063	+4.887	<.001	.009	3	1
LARGE_INTESTINE	TKTL2 →	+0.051	+4.509	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CLC by ETS1 expression — OESOPHAGUS

Explore this box plot interactively →