ESS2

Across TCGA patient cohorts, ESS2 mutation is significantly associated with the RNA expression of many other genes, with 3,373 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESS2-associated genes across cancer lineages are PER1, GANAB, and RN7SL248P. Each is linked with ESS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESS2-to-partner and partner-to-ESS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PER1 grouped by ESS2-low versus ESS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESS2→partner) and Y-score (partner→ESS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PER1 →	+0.854	+3.604	<.001	.001	3	3
UCEC	GANAB →	+0.445	+2.625	.007	.005	3	3
UCEC	RN7SL248P →	+0.054	+3.059	<.001	.005	3	2
UCEC	TMEM269 →	+0.142	+3.739	.007	<.001	3	2
LUSC	RNU6-306P →	+0.373	+5.404	<.001	.005	3	2
SKCM	FTH1P9 →	+0.031	+4.769	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,373 associations by consensus.

PER1 by ESS2 expression — SKCM

Explore this box plot interactively →