ESRRB

Across TCGA patient cohorts, ESRRB mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESRRB-associated genes across cancer lineages are Caspase-7-cleavedD198, p62 Lck ligand, and A-Raf_pS299. Each is linked with ESRRB in more than 3 cancer types. Because this analysis shows association rather than direction, both ESRRB-to-partner and partner-to-ESRRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ESRRB-low versus ESRRB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRRB→partner) and Y-score (partner→ESRRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.932	+3.019	<.001	<.001	3	4
UCEC	p62 Lck ligand →	+0.297	+2.070	.008	.001	3	3
UCEC	A-Raf_pS299 →	-0.124	-1.807	.002	.025	3	2
UCEC	JNK_pT183_Y185 →	-0.237	-2.446	<.001	<.001	3	2
SKCM	MIG-6 →	+0.186	+2.602	.011	.006	3	2
UCEC	Notch1 →	+0.153	+1.424	.001	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by ESRRB expression — UCEC

Explore this box plot interactively →