ESRRB

Across TCGA pan-cancer cohorts, ESRRB RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ESRRB data layer compared with 5 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher ESRRB RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ESRRB expression acts as an unfavorable survival marker, although some lineages such as KIRP and CESC show a favorable association.

THCA, THYM, and LGG are the cancer types where ESRRB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	II,III,IV	0.887	1.000	.001	62	view →
THYM	DFS	Median	All	0.824	0.976	<.001	39	view →
LGG	DFS	Median	All	0.335	0.460	<.001	37	view →
UCEC	DFS	Quartile	All	0.518	0.811	<.001	36	view →
KIRP	DFS	Tertile	II,III,IV	0.853	0.177	.018	36	view →
COAD	DFS	Tertile	All	0.294	0.736	.005	33	view →
CESC	OS	Quartile	All	0.869	0.706	.011	30	view →
LUAD	OS	Median	II,III,IV	0.418	0.162	.012	20	view →
CHOL	OS	Median	III,IV	1.000	0.286	.008	18	view →
LIHC	OS	Tertile	All	0.766	0.537	.006	18	view →
SKCM	OS	Median	II,III,IV	0.391	0.236	.014	17	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ESRRB–THCA (OS)

Open the THCA breakdown →