ESRRB

Across TCGA cell cohorts, ESRRB mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESRRB-associated genes across cancer lineages are CHN2, C1QBP, and FBXL4. Each is linked with ESRRB in more than 1 cancer types. Because this analysis shows association rather than direction, both ESRRB-to-partner and partner-to-ESRRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHN2 grouped by ESRRB-low versus ESRRB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRRB→partner) and Y-score (partner→ESRRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHN2 →	-1.028	-3.278	.006	.006	3	1
LARGE_INTESTINE	C1QBP →	+0.805	+3.451	<.001	.002	3	1
LARGE_INTESTINE	FBXL4 →	+0.528	+3.364	.001	.002	3	1
LARGE_INTESTINE	FBXO25 →	+0.942	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CCNO →	+1.044	+3.364	.001	.002	3	1
LARGE_INTESTINE	MCOLN2 →	+1.543	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

CHN2 by ESRRB expression — LARGE_INTESTINE

Explore this box plot interactively →