ESRRA

Across TCGA patient cohorts, ESRRA mutation is significantly associated with the RNA expression of many other genes, with 407 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESRRA-associated genes across cancer lineages are RNU6-15P, MTHFD2P3, and RN7SKP297. Each is linked with ESRRA in more than 2 cancer types. Because this analysis shows association rather than direction, both ESRRA-to-partner and partner-to-ESRRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-15P grouped by ESRRA-low versus ESRRA-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRRA→partner) and Y-score (partner→ESRRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-15P →	+0.313	+4.372	.009	.007	3	3
UCEC	MTHFD2P3 →	+0.284	+3.567	<.001	.001	3	3
HNSC	RN7SKP297 →	+0.156	+4.736	<.001	.007	3	2
CESC	ANP32BP2 →	+0.077	+5.201	<.001	.007	3	2
HNSC	ELAVL4-AS1 →	+0.077	+5.449	<.001	<.001	3	2
CESC	EEF1E1-BLOC1S5 →	+0.060	+5.969	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 407 associations by consensus.

RNU6-15P by ESRRA expression — HNSC

Explore this box plot interactively →