ESRRA

Across TCGA cell cohorts, ESRRA mutation is significantly associated with the mutation status of many other genes, with 3,613 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ESRRA-associated genes across cancer lineages are SLC9A1, POLR3E, and YIPF1. Each is linked with ESRRA in more than 2 cancer types. Because this analysis shows association rather than direction, both ESRRA-to-partner and partner-to-ESRRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC9A1 grouped by ESRRA-low versus ESRRA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRRA→partner) and Y-score (partner→ESRRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC9A1 →	+3.338	+4.083	.003	.003	1	3
BLOOD_Leukemia	POLR3E →	+4.145	+4.635	.001	.001	1	3
BLOOD_Leukemia	YIPF1 →	+5.560	+4.736	.003	.003	1	3
LARGE_INTESTINE	SLK →	+2.652	+3.471	.004	.004	1	3
BLOOD_Leukemia	VPS35 →	+4.560	+4.309	.007	.007	1	3
BLOOD_Lymphoma	GALNT7 →	+5.584	+5.014	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,613 associations by consensus.

SLC9A1 by ESRRA expression — BLOOD_Leukemia

Explore this box plot interactively →