ESRP2

Across TCGA patient cohorts, ESRP2 mutation is significantly associated with the RNA expression of many other genes, with 2,797 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESRP2-associated genes across cancer lineages are UHRF1, RCC1, and MEX3D. Each is linked with ESRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESRP2-to-partner and partner-to-ESRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by ESRP2-low versus ESRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRP2→partner) and Y-score (partner→ESRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.701	+1.654	<.001	.002	3	2
UCEC	RCC1 →	+0.371	+2.370	.006	.003	3	2
UCEC	MEX3D →	+0.522	+3.021	.001	<.001	3	2
SKCM	NOP10 →	+0.527	+3.341	.001	.005	3	2
UCEC	NDUFA6 →	+0.466	+2.523	<.001	<.001	3	2
UCEC	FAF1 →	+0.336	+2.606	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,797 associations by consensus.

UHRF1 by ESRP2 expression — UCEC

Explore this box plot interactively →