ESR2

Across TCGA patient cohorts, ESR2 protein abundance is significantly associated with the RNA expression of many other genes, with 653 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ESR2-associated genes across cancer lineages are KLC2, APBA3, and FILIP1. Each is linked with ESR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESR2-to-partner and partner-to-ESR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ESR2 versus KLC2 in LUAD, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR2→partner) and Y-score (partner→ESR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KLC2 →	+0.397	+1.019	.008	.007	3	2
UCEC	APBA3 →	+0.531	+0.753	.007	.007	3	1
UCEC	FILIP1 →	-0.877	-0.690	.001	.002	3	1
UCEC	DCAF4 →	+0.503	+0.821	<.001	.001	3	1
UCEC	EEPD1 →	+1.143	+0.971	.005	.002	3	1
UCEC	ACAP3 →	+0.837	+0.820	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 653 associations by consensus.

ESR2 vs KLC2 — LUAD

Explore this scatter interactively →