ESR1

Across TCGA patient cohorts, ESR1 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,627 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ESR1-associated proteins across cancer lineages are OLFML1, SNX18, and SNX9. Each is linked with ESR1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ESR1-to-partner and partner-to-ESR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ESR1 versus OLFML1 in HNSC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR1→partner) and Y-score (partner→ESR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OLFML1 →	+0.778	+0.765	<.001	<.001	3	6
PDAC	SNX18 →	+0.287	+0.355	<.001	<.001	3	6
LSCC	SNX9 →	+0.330	+0.649	<.001	<.001	3	6
LSCC	WIPF1 →	+0.353	+0.603	<.001	<.001	3	6
BRCA	MAPKAPK2 →	+0.268	+2.365	<.001	<.001	3	6
COAD	ASPN →	+0.842	+0.175	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,627 associations by consensus.

ESR1 vs OLFML1 — HNSC

Explore this scatter interactively →