ESR1

Across TCGA pan-cancer cohorts, ESR1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ESR1 data layer compared with 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ESR1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ESR1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LIHC show a favorable association.

UCEC, LIHC, and HNSC are the cancer types where ESR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.747	0.555	<.001	108	view →
LIHC	OS	Median	All	0.784	0.587	<.001	108	view →
HNSC	DFS	Tertile	All	0.729	0.538	<.001	96	view →
SKCM	OS	Median	All	0.397	0.272	<.001	49	view →
LGG	DFS	Median	All	0.779	0.882	<.001	48	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
ACC	DFS	Quartile	All	0.145	0.693	<.001	35	view →
BRCA	DFS	Quartile	III,IV	0.935	0.763	.001	33	view →
ESCA	DFS	Tertile	III,IV	0.622	0.341	.004	33	view →
CESC	DFS	Quartile	IV	0.784	0.258	.002	24	view →
DLBC	DFS	Tertile	III,IV	0.256	0.984	.013	18	view →
OV	OS	Median	IV	0.622	0.867	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ESR1–UCEC (DFS)

Open the UCEC breakdown →