ESR1

Across TCGA patient cohorts, ESR1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,130 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ESR1-associated genes across cancer lineages are SCGB2A1, SYBU, and AR. Each is linked with ESR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESR1-to-partner and partner-to-ESR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ESR1 versus SCGB2A1 in UCEC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR1→partner) and Y-score (partner→ESR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCGB2A1 →	+2.024	+0.516	<.001	<.001	3	3
BRCA	SYBU →	+1.543	+0.894	<.001	<.001	3	3
BRCA	AR →	+1.902	+0.942	<.001	<.001	3	3
BRCA	NCCRP1 →	-1.917	-1.117	<.001	<.001	3	3
UCEC	CFAP43 →	+1.588	+0.541	<.001	<.001	3	3
UCEC	CYTOR →	-0.626	-0.592	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,130 associations by consensus.

ESR1 vs SCGB2A1 — UCEC

Explore this scatter interactively →