ESR1

Across TCGA patient cohorts, ESR1 mutation is significantly associated with the RNA expression of many other genes, with 1,437 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESR1-associated genes across cancer lineages are RNA5SP412, HPF1, and GPR135. Each is linked with ESR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESR1-to-partner and partner-to-ESR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by ESR1-low versus ESR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR1→partner) and Y-score (partner→ESR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.473	+1.645	<.001	.003	3	3
COAD	HPF1 →	+0.491	+3.459	.006	.005	3	3
UCEC	GPR135 →	-0.323	-1.455	.003	.005	3	3
UCEC	SERF1AP1 →	+0.085	+2.109	.007	.006	3	3
UCEC	RNA5SP413 →	+0.969	+1.692	<.001	<.001	3	3
UCEC	RNA5SP422 →	+0.573	+1.732	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,437 associations by consensus.

RNA5SP412 by ESR1 expression — UCEC

Explore this box plot interactively →