ESR1

Across TCGA patient cohorts, ESR1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESR1-associated genes across cancer lineages are SF2, eEF2, and ERK2. Each is linked with ESR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESR1-to-partner and partner-to-ESR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by ESR1-low versus ESR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR1→partner) and Y-score (partner→ESR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF2 →	-0.088	-1.574	.012	.034	3	3
COAD	eEF2 →	+0.448	+3.330	.001	.005	3	2
UCEC	ERK2 →	+0.151	+2.000	.015	.029	3	2
UCEC	INPP4B →	-0.309	-2.906	.003	.001	3	2
UCEC	MEK1 →	+0.252	+1.362	.033	.034	3	2
COAD	MSH2 →	-0.285	-3.000	.006	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

SF2 by ESR1 expression — UCEC

Explore this box plot interactively →