ESR1

Across TCGA cell cohorts, ESR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,238 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ESR1-associated GO terms across cancer lineages are Negative regulation of autophagy, Endosome organization, and Endosomal transport. Each is linked with ESR1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ESR1-to-partner and partner-to-ESR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by ESR1-low versus ESR1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR1→partner) and Y-score (partner→ESR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Negative regulation of autophagy →	+0.073	+0.229	<.001	.001	3	9
KIDNEY	Endosome organization →	+0.064	+0.176	.005	<.001	2	10
BONE	Endosomal transport →	+0.062	+0.338	.006	.004	3	8
OESOPHAGUS	Cerebral cortex radially oriented cell migration →	+0.139	+0.879	.003	.006	3	8
OESOPHAGUS	Protein localization to vacuole →	+0.116	+1.132	<.001	.007	2	9
BONE	Protein targeting to vacuole →	+0.074	+0.263	.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,238 associations by consensus.

Negative regulation of autophagy by ESR1 expression — CNS

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