ESR1

Across TCGA cell cohorts, ESR1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESR1-associated genes across cancer lineages are CST9, IL22, and LRRC72. Each is linked with ESR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESR1-to-partner and partner-to-ESR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9 grouped by ESR1-low versus ESR1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR1→partner) and Y-score (partner→ESR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CST9 →	+0.006	+5.807	<.001	.001	3	1
STOMACH	IL22 →	+0.035	+4.285	<.001	.007	3	1
STOMACH	LRRC72 →	+0.070	+4.285	<.001	.007	3	1
LARGE_INTESTINE	RHOXF1 →	+0.191	+3.569	.003	.006	3	1
LARGE_INTESTINE	NEUROG1 →	+0.012	+3.099	<.001	.002	3	1
LARGE_INTESTINE	ZAR1 →	+0.171	+3.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CST9 by ESR1 expression — OVARY

Explore this box plot interactively →