Across TCGA pan-cancer cohorts, ESPN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ESPN data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ESPN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ESPN expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where ESPN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.936	0.477	.004	32	view →
LUAD	DFS	Quartile	All	0.866	0.346	.018	9	view →
CCRCC	OS	Tertile	III,IV	0.978	0.223	.036	3	view →
LSCC	OS	Median	II,III,IV	1.000	0.833	.049	1	view →
PDAC	OS	Median	II,III,IV	0.531	0.304	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ESPN tumor-vs-normal RNA expression · all ESPN data types