Across TCGA pan-cancer cohorts, ESPN RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ESPN’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ESPN RNA is repressed in tumor relative to normal tissue. In most cancer types ESPN is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.
KIRP, THCA, and LUAD are the cancer types where ESPN tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ESPN RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.