Across TCGA patient cohorts, ESPN RNA expression is significantly associated with the protein abundance of many other proteins, with 11,673 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ESPN-associated proteins across cancer lineages are ESPN_S342, ESPN_T649, and MYH14. Each is linked with ESPN in more than 5 cancer types. Because this analysis shows association rather than direction, both ESPN-to-partner and partner-to-ESPN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPN→partner) and Y-score (partner→ESPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ESPN_S342 →	+1.204	+1.059	<.001	<.001	3	6
PDAC	ESPN_T649 →	+2.261	+1.107	.001	.001	3	6
CCRCC	MYH14 →	+0.720	+0.925	<.001	<.001	3	4
COAD	TOMM34 →	+0.381	+0.705	<.001	.001	3	4
CCRCC	PIK3R1_Y556 →	-0.541	-1.083	<.001	<.001	3	4
UCEC	DHRS3 →	+0.495	+0.779	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,673 associations by consensus.

Exploration

ESPN survival (RNA) · tumor vs normal (RNA) · all ESPN data types