Across TCGA patient cohorts, ESPN protein abundance is significantly associated with the RNA expression of many other genes, with 5,725 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ESPN-associated genes across cancer lineages are GALE, HES2, and AGMAT. Each is linked with ESPN in more than 4 cancer types. Because this analysis shows association rather than direction, both ESPN-to-partner and partner-to-ESPN results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPN→partner) and Y-score (partner→ESPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GALE →	+0.965	+0.722	.002	.002	3	5
UCEC	HES2 →	+1.450	+0.858	<.001	<.001	3	5
CCRCC	AGMAT →	+0.963	+0.458	.003	<.001	3	4
UCEC	PLEKHG5 →	+1.039	+0.870	<.001	<.001	3	4
UCEC	PRXL2B →	+0.780	+0.627	<.001	<.001	3	4
CCRCC	AKR7A3 →	+0.874	+0.298	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,725 associations by consensus.

Exploration

ESPN survival (RNA) · tumor vs normal (RNA) · all ESPN data types