Across TCGA patient cohorts, ESPN mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESPN-associated genes across cancer lineages are Annexin-1, 4E-BP1_pT37_T46, and Cyclin-B1. Each is linked with ESPN in more than 1 cancer types. Because this analysis shows association rather than direction, both ESPN-to-partner and partner-to-ESPN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPN→partner) and Y-score (partner→ESPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.873	+3.720	<.001	<.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.492	-3.446	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.689	+2.700	.001	.006	3	2
UCEC	eIF4G →	+0.277	+3.169	.023	.018	3	1
UCEC	ERK2 →	+0.207	+2.459	.006	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.134	-2.000	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

ESPN survival (RNA) · tumor vs normal (RNA) · all ESPN data types