ESPN

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, ESPN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,228 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ESPN-associated GO terms across cancer lineages are Microvillus assembly, Microvillus organization, and Cytotoxic T cell degranulation. Each is linked with ESPN in more than 12 cancer types. Because this analysis shows association rather than direction, both ESPN-to-partner and partner-to-ESPN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPN→partner) and Y-score (partner→ESPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
KIDNEYMicrovillus assembly →-0.174-1.465.009.006213
OVARYMicrovillus organization →-0.239-1.756<.001<.001310
LIVERCytotoxic T cell degranulation →+0.229+3.342.003.001310
OESOPHAGUSRegulation of intrinsic apoptotic signaling pathway →+0.047+1.401.004.00339
OESOPHAGUSEstablishment or maintenance of epithelial cell apical/basal polarity →+0.128+2.143.002<.00139
KIDNEYRegulation of corticotropin secretion →-1.180-1.181.002.00939
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,228 associations by consensus.

Exploration