Across TCGA cell cohorts, ESPN mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ESPN-associated genes across cancer lineages are WNT2, CRISP2, and CYP1A2. Each is linked with ESPN in more than 1 cancer types. Because this analysis shows association rather than direction, both ESPN-to-partner and partner-to-ESPN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPN→partner) and Y-score (partner→ESPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WNT2 →	+0.640	+3.426	.002	.007	3	1
SKIN	CRISP2 →	+0.214	+4.052	<.001	<.001	3	1
SKIN	CYP1A2 →	+0.056	+4.353	<.001	.001	3	1
SKIN	CALHM4 →	+0.057	+3.813	.001	.003	3	1
SKIN	OR4F6 →	+0.011	+3.217	.006	.006	3	1
SKIN	KRTAP5-5 →	+0.010	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

ESPN survival (RNA) · tumor vs normal (RNA) · all ESPN data types