ESPL1

Across TCGA pan-cancer cohorts, ESPL1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ESPL1 data layer compared with 27 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ESPL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ESPL1 expression acts as an unfavorable survival marker.

UCEC, HNSC, and LUAD are the cancer types where ESPL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.353	0.942	.025	8	view →
HNSC	DFS	Median	III,IV	0.711	0.896	.024	6	view →
LUAD	DFS	Median	All	0.572	0.945	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ESPL1–UCEC (DFS)

Open the UCEC breakdown →