ESM1

Across TCGA patient cohorts, ESM1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,544 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ESM1-associated proteins across cancer lineages are LOXL2, PLOD2, and VEGFA. Each is linked with ESM1 in more than 7 cancer types. Because this analysis shows association rather than direction, both ESM1-to-partner and partner-to-ESM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ESM1 versus LOXL2 in HNSC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ESM1→partner) and Y-score (partner→ESM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LOXL2 →	+0.789	+1.148	<.001	<.001	3	8
HNSC	PLOD2 →	+0.977	+1.098	<.001	<.001	3	8
OV	VEGFA →	+1.096	+1.581	<.001	<.001	3	8
OV	FLT1 →	+0.794	+1.292	<.001	<.001	3	8
PDAC	ANGPT2 →	+1.003	+1.739	<.001	<.001	3	7
BRCA	P4HA1 →	+0.702	+1.218	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,544 associations by consensus.

ESM1 vs LOXL2 — HNSC

Explore this scatter interactively →