ESM1

Across TCGA pan-cancer cohorts, ESM1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ESM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ESM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ESM1 is over-expressed in tumor.

KIRC, BLCA, and HNSC are the cancer types where ESM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ESM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+4.445	<.001	12	view →
BLCA	Male	III,IV	+4.271	<.001	12	view →
HNSC	Female	IV	+2.686	<.001	12	view →
COAD	Male	III,IV	+3.063	<.001	11	view →
LIHC	Female	II,III,IV	+2.971	<.001	9	view →
STAD	Male	III,IV	+2.935	<.001	9	view →
THCA	Male	All	+2.331	<.001	8	view →
READ	Male	All	+4.180	<.001	7	view →
UCEC	All	II,III,IV	+3.252	<.001	6	view →
BRCA	All	III,IV	+2.480	<.001	6	view →
KICH	All	All	+1.118	.001	4	view →
CHOL	All	All	+2.961	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ESM1–KIRC

Open the KIRC breakdown →