ESM1

Across TCGA patient cohorts, ESM1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,417 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ESM1-associated genes across cancer lineages are APLN, PTPRN, and FLT1. Each is linked with ESM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ESM1-to-partner and partner-to-ESM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ESM1 versus APLN in BRCA, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESM1→partner) and Y-score (partner→ESM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	APLN →	+1.221	+1.233	<.001	<.001	3	5
LSCC	PTPRN →	+0.499	+1.042	<.001	<.001	3	4
CCRCC	FLT1 →	+0.764	+0.550	.004	.004	3	4
LUAD	VEGFA →	+1.317	+0.956	<.001	<.001	3	4
UCEC	CD40LG →	-0.965	-1.441	.007	.002	3	3
UCEC	SKP2 →	+0.868	+1.346	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,417 associations by consensus.

ESM1 vs APLN — BRCA

Explore this scatter interactively →