ESM1

Across TCGA cell cohorts, ESM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,972 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ESM1-associated GO terms across cancer lineages are Regulation of fibrinolysis, Positive regulation of cytoskeleton organization, and Plasminogen activation. Each is linked with ESM1 in more than 7 cancer types. Because this analysis shows association rather than direction, both ESM1-to-partner and partner-to-ESM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fibrinolysis grouped by ESM1-low versus ESM1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESM1→partner) and Y-score (partner→ESM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of fibrinolysis →	+0.298	+1.252	<.001	.007	3	8
BONE	Positive regulation of cytoskeleton organization →	+0.063	+1.373	<.001	.002	3	8
LUNG_NSCLC_LUAD	Plasminogen activation →	+0.240	+0.815	<.001	.007	3	7
BONE	Positive regulation of cell-substrate junction organization →	+0.187	+0.981	<.001	.004	3	7
BONE	Regulation of matrix metallopeptidase secretion →	-0.313	-1.865	<.001	.003	3	7
BONE	Fibrinolysis →	+1.213	+1.272	.002	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,972 associations by consensus.

Regulation of fibrinolysis by ESM1 expression — BONE

Explore this box plot interactively →